We are a commune of inquiring, skeptical, politically centrist, capitalist, anglophile, traditionalist New England Yankee humans, humanoids, and animals with many interests beyond and above politics. Each of us has had a high-school education (or GED), but all had ADD so didn't pay attention very well, especially the dogs. Each one of us does "try my best to be just like I am," and none of us enjoys working for others, including for Maggie, from whom we receive neither a nickel nor a dime. Freedom from nags, cranks, government, do-gooders, control-freaks and idiots is all that we ask for.
Now you may soon be able to vacation parlinson's disease free at any of the locations on Vacation rentals by Owner.
Great news !!!
SLU-WU team finds Parkinson's trigger
By Greg Jonsson
ST. LOUIS POST-DISPATCH
St. Louis — Researchers here say they have pinpointed the brain chemical that triggers Parkinson's disease, opening the door to better treatments for the debilitating neurological disorder.
Parkinson's disease is caused when brain cells that produce the chemical messenger dopamine die off. Deprived of this important brain chemical, patients develop symptoms such as tremors, slowness of movement, rigidity and impaired balance. About 1.5 million Americans have Parkinson's disease, which grows worse over time.
Most treatments focus on replacing the chemical, but now researchers say they know what causes the cells to die and believe there are drugs that can help keep the cells alive.
"We've solved a basic puzzle in Parkinson's," said Dr. William J. Burke, a member of the team of St. Louis University and Washington University researchers who found the chemical responsible. "I think it's tremendously significant. Once you know how a disease process works, you can attack the disease. Now that we have scientific evidence of how this works, it provides a rational basis for therapy."
Part of the mystery of Parkinson's disease was why only dopamine neurons die off while billions of other neurons in the brain aren't affected.
The culprit, according to the study published in an early online edition of the journal Acta Neuropathologica, begins with dopamine itself. Dopamine can be converted to a chemical called DOPAL, which in turn causes a specific protein found in the brain to form toxic clumps that kill dopamine-producing cells. Other neurons aren't decimated by this process because they don't contain dopamine or DOPAL.
Understanding the process that causes the disease can aid researchers in developing treatments to block or break down DOPAL — preventing neurons from dying off instead of simply replacing the missing dopamine in Parkinson's patients.
Some researchers had found that drugs help combat Parkinson's without knowing exactly why or how they help. It turns out they stop DOPAL. Now that the St. Louis researchers have pinpointed the chemical, those drugs can be employed more effectively and new drugs can be developed, said Burke, a researcher at SLU.
"Drugs are available that are already FDA-approved that give hope of slowing or stopping Parkinson's disease," he said.
Others have theorized that dopamine and/or the protein played a role, but the St. Louis researchers isolated DOPAL as the trigger that caused the clumping of the protein, and thus the death of neurons.
First, they put DOPAL and the protein in test tubes and found that the protein formed clumps. Other chemicals they tried did not cause the clumping.
Then they found that DOPAL caused clumping of the protein in cultures of dopamine cells. Finally, they injected DOPAL in specific parts of rat brains and then looked closely at the neurons. They found dopamine neurons had died, and they saw toxic clumps of the protein.
Other researchers involved in the study include Vijaya B. Kumar, W. Michael Panneton, Shu W. Li, Yi Pan, Hyung D. Chung, Qi Gan and Mark W. Franko of SLU, and Neeraj Pandey, James E. Galvin and Mark O'Dell of Washington University.
2003? Well I'm glad to hear that Kampala is A-OK..but to make sure would you go ahead and scout out the $2400/week accommodations, get out in the bush a bit, mix with the locals...you know just check it out for the Griswalds.