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Pulmonary emboli, from from deep vein clots, are serious if not fatal.
Because aspirin reduces platelet aggregation, it would seem sensible to take 81 mg before long sedentary periods. However, studies do not confirm that.
Many people die in their late 50's and 60's because of blood clots. Many more suffer serious medical complications for the same reason. It is far safer to take the baby aspirin then it is to not take it.
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Paleo's right . A single 81 mg aspirin won't do much - it's only effective if taken daily .
Personally, I take two standard aspirin before a long flight - both for blood thinning and to preemptively treat the muscle and lower back soreness I get from prolonged sitting .
I suffer from Deep Vein Thrombosis in one leg, for which my doctor has me take one daily 81mg aspirin. For flights and long car drives he has me take Xeraltro 2 hours before the flight/car drive. To not overdo things (you can thin the blood too much and risk bleeding out from a paper cut) I need to stop aspirin the day before and day of taking Xeraltro.