Blues is not about sadness. Blues is about releasing the energy of true feelings. Blues is about sharing your soul. Nina Simone was one of the best.
Last night's Chuck ending scene melded Nina Simone's Feeling Good with the feelings shared by Chuck and Sarah (IMHO, the hottest, realest woman in any TV series).
You can catch it after the 41st minute:
http://www.nbc.com/chuck/video/chuck-versus-the-honeymooners/1222679/
For the whole Feeling Good, try this YouTube: