Prof. Lee Smolin has doubts: Think About Nature.
The problem that I've identified—that I think is at the root of a lot of the spinning of our wheels and confusion of contemporary physics and cosmology—is that you can't just take this method of doing science and scale it up to the universe as a whole. When you do, you run into questions that you can't answer. You end up with fallacies; you end up saying silly things. One reason is that, on a cosmological scale, the questions that we want to understand are not just what are the laws, but why are these the laws rather than other laws? Where do the laws come from? What makes the laws what they are? And if the laws are input to the method, the method will never explain the laws because they're input.