Edward Feser, author of Locke, asks the above question in a dense, meaty, scholarly piece at TCS which takes more than a couple of minutes to absorb. His conclusion:
Those who seek to appropriate Locke's legacy today must decide which part of it they value most, for they cannot coherently have it all. One must either endorse Locke's revisionist metaphysics - his rejection of objective essences and final causes in nature, his reductionistic account of the nature of persons, and so forth - and abandon the traditional moral and religious elements of his philosophy; or, if one wants to maintain these conservative elements, one must reject the revisionist metaphysics, and return to something like the Scholastic worldview it replaced. One must be either a radical or a reactionary. It is no longer possible (if it ever was) to be a Lockean.