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Friday, June 18. 2021

A new medicine for fat loss


Ozempic (semaglutide) had been approved by the FDA for Type 2 diabetes, but now it has also been approved for treatment of overweight and obesity provided you have 1 weight-related problem (which could include arthritis, etc.).


It comes as a (tiny) weekly injection, done at home. 


It is mainly an appetite-suppressant, and a highly-effective one according to a couple of patients. It can have some GI side-effects, but is usually tolerated.


It is something to consider for those who have too much trouble with food. As we have often said, it's impossible to burn off dangerous deep fat with exercise.



Posted by Dr. Joy Bliss in Medical at 15:01 | Comments (9) | Trackbacks (0)

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I went from 25 mg glyburide to 1.0 mg Ozempic and lost over 60 lbs. while also taking Metformin and Jarrdiance.
#1 Jim on 2021-06-18 18:53 (Reply)
Jim, congratulations! As one who gains and losses 15-20 pounds every three or four years, I am genuinely happy for your success. Take care and stay well.
#1.1 Martha Lynn Johnson (Link) on 2021-06-18 21:01 (Reply)
An MD friend says,"I prescribe Ozempic all the time for type 2 diabetics. Great new indication. Good for about 10 KG weight loss & maybe even up to 10-15% total body weight loss in some people.

Great drug. Now there is also an oral in this drug class."
#2 feeblemind on 2021-06-18 21:47 (Reply)
We all know what we need to do to lose weight. I lost 50 after I got married, no sugar, few carbs and grrrr no booze. Not onerous but not a lot of fun either. Gained 20 back and can hold there. Very leery of anything that “delays gastric emptying”….no need of that thank you very much.
#2.1 DblTap on 2021-06-19 11:50 (Reply)
From articles on this drug, I see that there are the usual possible side effects from the use of this drug but nothing too alarming, so why is the FDA restricting the use of this drug to those who are overweight and have some other condition? Why is weight loss all by itself not a sufficient reason for using this drug?
#3 Jerryskids on 2021-06-19 07:48 (Reply)
The FDA hasn't restricted the drug's use. They simply haven't approved it. FDA approval would mean that third party payors would generally have to pay for it (barring some policy stipulation to the contrary). Physicians are free to use the drug for "off-label" indications*

*In my ideal world, a physician prescription would not be needed for medications. Barring some negative public health implication, e.g. resistant strains of bacteria, people would have the right to medicate themselves...and they would have the responsibility for any adverse consequences.
#3.1 mike m on 2021-06-20 10:25 (Reply)
All drugs of this class delay gastric emptying, so people feel full longer. Not news, really. In my GI practice I see pts all the time for nausea, abd pain, bloating, etc who can be cured by changing their diabetes drug.
#4 Khornet on 2021-06-19 07:51 (Reply)
Isn't Ozempic really expensive, as in $1,000 per month expensive?
#5 snopercod on 2021-06-19 12:57 (Reply)
The single best investment I made in weight loss was a good scale.

Once I started weighing my food and seeing what I was really eating, I focused on changing my diet. No amount of exercise would work because cardio exercise raises hunger levels by an offsetting amount seemingly. (short HIIT is an exception)

Once I committed to truly measuring my intake and adding some low cal, high volume foods like salad or grilled poblanos to make me feel full - the I could enjoy the foods I liked in moderation and still lose weight

Change in diet - not dieting - is the key to weight loss. If some of these drugs help build momentum that’s great, but I also wanted to make sure I didn’t have rebound (the way I always did with Keto diets)

Down 45 lbs today and enjoying my meals more …
#6 SingleHandedSailor on 2021-06-19 14:39 (Reply)

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