Definitely, at least for me. It was instantly noticeable when I got back to the gym, even though my break had almost daily 3-hour hikes, water play, and other activty.
Most noticeable were my deadlifts and bench press. Just more evidence of "use it or lose it", especially over 40.
Just image the effect of years without workouts.
It's kinda depressing, but I got back to my daily routines.