Distance running, like any extended-time cardio (eg swimming, elliptical, rowing, bike, etc), procures no health or fitness benefits. Worse, distance running damages the body, often permanently.
Don’t Run a Marathon. You have better things to do.
If you must use running for the cardio component of a fitness program, two to four quarter-mile or even half-mile sprints per week is plenty. Treadmill sprints are kinder on the joints than a road. The comparable anaerobic sprint approach applies to any cardio exercises. For cardio, it is the spurts of max. intensity that matter, not time wasted.
(I am reminded to add that, for those over 75 or 80, aerobic cardio is great and much better than sitting.)