In Psychiatry today there is much discussion, debate, and confusion about diagnosing the varieties of serious mood or attitudinal instability (ie instability which is life-disrupting in some significant way).
It's not your grandfather's Bipolar Disorder anymore. The numbers of people labelled as "Bipolar spectrum" has increased dramatically, for better or worse, in recent years. It may be "diagnosis creep," or it might be better understanding. A complicating factor is the overlap between Bipolar Spectrum problems and Borderline Personality, discussed here, where flips in attitudes towards relationships (eg idealization and devaluation) can be prominent in both (along with volatility, grandiosity, hypersensitivity, rage and paranoia).
All of this mess can be treated. I have become a fan of Lamictal for mood instability and attitude shifts which do not rise to the level of full-blown Manic-Depression but which are well-outside the normal moods and shifts of daily life. Lamictal plus confrontational psychotherapy, and maybe an antidepressant.
Here's Hornbacher's book, Madness: A Bipolar Life
I often wonder what such peoples' lives (mostly women) were like before modern treatments. Not too good, I suspect, in the absence of a loyal spouse.