From an essay of the above name by Craig and Fennell in The New Atlantis, which uses Wolfe's novel as a springboard for a discussion of cultural issues, but let me say that I hated the book, but I enjoy Wolfe's writing very much - the book was just too disgustingly real:
"I Am Charlotte Simmons is an indictment of the primary centers of higher education in America today. These institutions do not well serve the real longings and earnest ambitions of the young people who flock to them, at great cost and with great expectations, year after year. Instead of pointing students to a world that is higher than where they came from, the university reinforces and expands the nihilism and political correctness that they are taught in public schools, imbibe from popular culture, and bring with them as routine common sense when they arrive on campus. Of course, these two ideologies are largely incompatible: nihilism celebrates strength (or apathy) without illusion; political correctness promulgates illusions in the name of sensitivity. But both ideologies are the result of collapsing and rejecting any distinction between higher and lower, between nobility and ignobility, between the higher learning and the flight from reason."
Read entire.