I am not a knowledge-nihilist, but readers know that I take everything I hear with a grain of salt. Stupid not to.
The big thing in recent years for theoretical physicists is the replacement of the notion of the "universe" with the notion of the "multiverse." A quote from The accidental universe: Science's crisis of faith:
The history of science can be viewed as the recasting of phenomena that were once thought to be accidents as phenomena that can be understood in terms of fundamental causes and principles. One can add to the list of the fully explained: the hue of the sky, the orbits of planets, the angle of the wake of a boat moving through a lake, the six-sided patterns of snowflakes, the weight of a flying bustard, the temperature of boiling water, the size of raindrops, the circular shape of the sun. All these phenomena and many more, once thought to have been fixed at the beginning of time or to be the result of random events thereafter, have been explained as necessary consequences of the fundamental laws of nature—laws discovered by human beings.
This long and appealing trend may be coming to an end. Dramatic developments in cosmological findings and thought have led some of the world’s premier physicists to propose that our universe is only one of an enormous number of universes with wildly varying properties, and that some of the most basic features of our particular universe are indeed mere accidents—a random throw of the cosmic dice. In which case, there is no hope of ever explaining our universe’s features in terms of fundamental causes and principles.
Read the whole thing. Science fiction, epistemology, God - it's all on the table. All uplifting, bedazzling, profoundly confusing, and probably more the stuff of poetry than of prose. I have no doubt that Really Big Reality is beyond human perception, comprehension or imagination. I am prone to term that swirl of transendent incomprehensibility "God." Not a tame lion, as CS Lewis said. Sometimes reality seems mystical, and labelled "mysticism" just a pale copy.
And, despite it all, we all get up in the morning, say our prayers, get dressed, grab a Dunkin, go to the gym, take a shower, and get to work. Even the theoretical physicists and the priests and minsters do it.