I have always contended that the most severe mental disorders, eg Autism and Schizophrenia, were wiring problems rather than chemical problems.
Finally, it is becoming a major field of study: The miswired brain.
In my view, we all have different wiring, and we all have some loose wires and short circuits and sparking, but some loose wires cause more problems than others. Some will just make you more interesting, but some will burn your house down.