A serious marathoner friend recently told me that she had leased one of these to train for the Boston Marathon (on Monday). She does 2/3 of her running on the road, and 1/3 on the G.
60 miles/week, plus pool running and swimming a mile every other day. Yes, she is slim and ripped, but prone to shin splints over 40-50 miles/week on the road. She tends to come in right behind "the elites," as runners term them.
She complains that her job interferes with her training. Luckily, her husband and 3 kids are jocks and thus good supporters.
The G was designed as a rehab machine. It's about effort without injury. Review of the anti-gravity treadmill here.
Pool running is cheaper. These things cost $75,000.